发明申请
US20100286203A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2--2H-INDAZOLE-7-CARBOXAMIDE
有权
2--2H-吲唑-7-羧酰胺的药学上可接受的盐
- 专利标题： PHARMACEUTICALLY ACCEPTABLE SALTS OF 2--2H-INDAZOLE-7-CARBOXAMIDE
- 专利标题（中）： 2--2H-吲唑-7-羧酰胺的药学上可接受的盐
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申请号： US12811922申请日： 2009-01-08
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公开(公告)号： US20100286203A1公开(公告)日： 2010-11-11
- 发明人: Jennifer R. Foley , Robert Darrin Wilson
- 申请人： Jennifer R. Foley , Robert Darrin Wilson
- 国际申请： PCT/GB09/00041 WO 20090108
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; C07D401/10 ; A61P35/00 ; A61P29/00 ; A61P9/10 ; A61P3/10 ; A61P25/28 ; A61P31/12
摘要：
The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
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