Invention Application
- Patent Title: Methods of Detecting Target Nucleic Acids
- Patent Title (中): 检测靶核酸的方法
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Application No.: US11685189Application Date: 2007-03-12
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Publication No.: US20100291548A1Publication Date: 2010-11-18
- Inventor: Muhammad A. Sharaf , Timothy M. Woudenberg , Khairuzzaman Bashar Mullah
- Applicant: Muhammad A. Sharaf , Timothy M. Woudenberg , Khairuzzaman Bashar Mullah
- Applicant Address: US CA Foster City
- Assignee: Applera Corporation
- Current Assignee: Applera Corporation
- Current Assignee Address: US CA Foster City
- Main IPC: C12Q1/68
- IPC: C12Q1/68

Abstract:
The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.
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