发明申请
US20100292233A1 DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS
审中-公开
作为S1P1激动剂的二氢-1H-吡咯并[1,2-A]吲哚-1-基羧酸衍生物
![DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS](/docs/US/2010-11-18/US20100292233A1/abs.jpg.600x600.jpg)
- 专利标题： DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS
- 专利标题（中）： 作为S1P1激动剂的二氢-1H-吡咯并[1,2-A]吲哚-1-基羧酸衍生物
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申请号： US12863637申请日： 2009-01-22
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公开(公告)号： US20100292233A1公开(公告)日： 2010-11-18
- 发明人: Robert M. Jones , Daniel J. Buzard , Andrew M. Kawasaki , Luis A. Lopez , Jeanne V. Moody , Lars Thoresen , Brett Ullman
- 申请人： Robert M. Jones , Daniel J. Buzard , Andrew M. Kawasaki , Luis A. Lopez , Jeanne V. Moody , Lars Thoresen , Brett Ullman
- 申请人地址： US CA San Diego
- 专利权人： ARENA PHARMACEUTICALS, INC.
- 当前专利权人： ARENA PHARMACEUTICALS, INC.
- 当前专利权人地址： US CA San Diego
- 国际申请： PCT/US09/00399 WO 20090122
- 主分类号： A61K31/4245
- IPC分类号： A61K31/4245 ; C07D487/04 ; A61K31/4439 ; A61K31/497 ; A61K31/5377 ; A61P37/00 ; A61P35/00 ; A61P29/00 ; A61P17/06 ; A61P1/04 ; A61P3/10 ; A61P9/10 ; A61P17/10 ; A61P31/00 ; A61P31/12
![DIHYDRO-1H-PYRROLO[1,2-A]INDOL-1-YL CARBOXYLIC ACID DERIVATIVES WHICH ACT AS S1P1 AGONISTS](/abs-image/US/2010/11/18/US20100292233A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to certain (1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, sepsis, myocardial infarction, ischemic stroke, acne, microbial infections or diseases and viral infections or diseases.
公开/授权文献
- US2312945A Measuring system 公开/授权日：1943-03-02
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