发明申请
US20100292473A1 PROCESS FOR PREPARING (2R,3S/2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL
有权
制备（2R，3S / 2S，3R）-2-（2,4-二氟苯基）-3-（5-氟代吡啶-4-基）-1-（1H-1,2,4-三唑-1-基） YL）BUTAN-2-OL
- 专利标题： PROCESS FOR PREPARING (2R,3S/2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL
- 专利标题（中）： 制备（2R，3S / 2S，3R）-2-（2,4-二氟苯基）-3-（5-氟代吡啶-4-基）-1-（1H-1,2,4-三唑-1-基） YL）BUTAN-2-OL
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申请号： US12797790申请日： 2010-06-10
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公开(公告)号： US20100292473A1公开(公告)日： 2010-11-18
- 发明人: Venkataraman Sundaram , Venkata Bhaskara Rao Uppala , Surya Prabhakar Akundi , Venkateswarlu Muvva , Vijayawardhan Chitta , Alekhya Donthula , Manoj Ramesh Kharkar , Surya Narayana Devarakonda , Subba Reddy Peddireddy
- 申请人： Venkataraman Sundaram , Venkata Bhaskara Rao Uppala , Surya Prabhakar Akundi , Venkateswarlu Muvva , Vijayawardhan Chitta , Alekhya Donthula , Manoj Ramesh Kharkar , Surya Narayana Devarakonda , Subba Reddy Peddireddy
- 申请人地址： IN Andhra Pradesh US NJ Bridgewater
- 专利权人： DR. REDDY'S LABORATORIES LIMITED,DR. REDDY'S LABORATORIES, INC.
- 当前专利权人： DR. REDDY'S LABORATORIES LIMITED,DR. REDDY'S LABORATORIES, INC.
- 当前专利权人地址： IN Andhra Pradesh US NJ Bridgewater
- 优先权： IN427/CHE/2005 20050413; IN887/CHE/2005 20050706
- 主分类号： C07D403/06
- IPC分类号： C07D403/06
摘要：
Voriconazole is prepared by a process comprising condensing 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to give (2R,3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-diflurophenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2-ol.
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