发明申请
- 专利标题: SHORTENED SYNTHESIS USING PARAFORMALDEHYDE OR TRIOXANE
- 专利标题(中): 使用对甲二醛或三氧化硫进行短路合成
-
申请号: US12304008申请日: 2007-06-05
-
公开(公告)号: US20100292499A1公开(公告)日: 2010-11-18
- 发明人: Seth C. Ennis , Cornelia Fuchs , Ralf Kanzler , Dean A. Johnson
- 申请人: Seth C. Ennis , Cornelia Fuchs , Ralf Kanzler , Dean A. Johnson
- 申请人地址: IE County Clare
- 专利权人: SCHWARZ PHARMA LTD.
- 当前专利权人: SCHWARZ PHARMA LTD.
- 当前专利权人地址: IE County Clare
- 优先权: EP06012053.2 20060612; IES2006/0435 20060612
- 国际申请: PCT/EP07/04976 WO 20070605
- 主分类号: C07C69/78
- IPC分类号: C07C69/78 ; C07C213/00
摘要:
The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.
公开/授权文献
- US08115028B2 Shortened synthesis using paraformaldehyde or trioxane 公开/授权日:2012-02-14
信息查询