发明申请
US20100292499A1 SHORTENED SYNTHESIS USING PARAFORMALDEHYDE OR TRIOXANE 有权
使用对甲二醛或三氧化硫进行短路合成

SHORTENED SYNTHESIS USING PARAFORMALDEHYDE OR TRIOXANE
摘要:
The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.
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