发明申请
US20100297108A1 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS
有权
提供AMYLOIDIDES和蛋白质聚集障碍患者特异性免疫应答的方法
- 专利标题： METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS
- 专利标题（中）： 提供AMYLOIDIDES和蛋白质聚集障碍患者特异性免疫应答的方法
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申请号： US12733437申请日： 2008-09-01
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公开(公告)号： US20100297108A1公开(公告)日： 2010-11-25
- 发明人: Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
- 申请人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
- 优先权： EP07017135.0 20070831
- 国际申请： PCT/EP2008/007127 WO 20080901
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/00 ; G01N33/53 ; C12P21/06 ; C12N5/0781 ; G01N33/566 ; C07K14/00
摘要：
A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
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