发明申请
- 专利标题： HUMANISED ANTIBODIES WITH ANTI-TUMOUR ACTIVITY
- 专利标题（中）： 具有抗肿瘤活性的人类抗体
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申请号： US12725192申请日： 2010-03-16
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公开(公告)号： US20100297134A1公开(公告)日： 2010-11-25
- 发明人: Adam W. Clarke , Anthony G. Doyle , Philip A. Jennings , Norbert Kienzle , Matthew Pollard
- 申请人： Adam W. Clarke , Anthony G. Doyle , Philip A. Jennings , Norbert Kienzle , Matthew Pollard
- 申请人地址： AU Macquarie Park
- 专利权人： CEPHALON AUSTRALIA PTY LTD
- 当前专利权人： CEPHALON AUSTRALIA PTY LTD
- 当前专利权人地址： AU Macquarie Park
- 优先权： AU2009901129 20090316
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; A61P35/00 ; G01N33/574
摘要：
The present invention provides humanised antibodies and binding domains thereof with anti-tumour activity. In particular the humanised antibodies have specific binding to and direct killing of human colon tumour cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumour models.
公开/授权文献
- US08470320B2 Humanised antibodies with anti-tumour activity 公开/授权日：2013-06-25
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