发明申请
- 专利标题: 2-AMINOOXAZOLINES AS TAAR1 LIGANDS
- 专利标题(中): 2-AMINOOXAZOLINES as TAAR1 LIGANDS
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申请号: US12789484申请日: 2010-05-28
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公开(公告)号: US20100311798A1公开(公告)日: 2010-12-09
- 发明人: Guillaume Décoret , Guido Galley , Katrin Groebke Zbinden , Roger Norcross
- 申请人: Guillaume Décoret , Guido Galley , Katrin Groebke Zbinden , Roger Norcross
- 优先权: EP09162061.7 20090605
- 主分类号: A61K31/421
- IPC分类号: A61K31/421 ; C07D263/28
摘要:
The invention relates to compounds of formula wherein R1, R2, R2′, X, Y, andn are as defined in the specification or to a pharmaceutically suitable acid addition salt thereof. The compounds of formula I are active on the TAAR1 receptor and are therefore suitable for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
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