发明申请
- 专利标题： AQUEOUS PREPARATION COMPRISING eMIP AS ACTIVE INGREDIENT
- 专利标题（中）： 包含eMIP作为主动成分的水质准备
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申请号： US12502959申请日： 2009-07-14
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公开(公告)号： US20100316592A1公开(公告)日： 2010-12-16
- 发明人: Teruo AKUTA , Yoshiko Aoki
- 申请人： Teruo AKUTA , Yoshiko Aoki
- 申请人地址： JP Tokyo
- 专利权人： ECI, Inc.
- 当前专利权人： ECI, Inc.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2009-143120 20090616
- 主分类号： A61K38/16
- IPC分类号： A61K38/16
摘要：
An objective of the present invention is to provide aqueous preparations comprising eMIP, a derivative of macrophage inflammatory protein 1α (MIP-1α) which has an immunopotentiation activity, and stabilizer(s). The present inventors conducted dedicated studies to achieve the above-described objective. As a result, the present inventors discovered that eMIP degradation is suppressed by addition of at least one or more additives selected from sodium chloride, L-histidine, L-arginine, L-arginine hydrochloride, L-lysine hydrochloride, citric acid, and sodium edetate (EDTA). Furthermore, the present inventors demonstrated that phosphate buffer of pH 5 to pH 7 is a preferable pH adjuster for the aqueous eMIP preparations of the present invention.