发明申请
US20100317069A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
有权
丙二酸,十六烷二胺和6-氨基酸的生物合成的微生物和方法
- 专利标题: MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID
- 专利标题(中): 丙二酸,十六烷二胺和6-氨基酸的生物合成的微生物和方法
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申请号: US12776365申请日: 2010-05-07
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公开(公告)号: US20100317069A1公开(公告)日: 2010-12-16
- 发明人: Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
- 申请人: Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
- 主分类号: C12P17/10
- IPC分类号: C12P17/10 ; C12N1/00 ; C12P13/00 ; C12P7/42
摘要:
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
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