发明申请
US20100317654A1 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
有权
1,4-DIAZA-BICYCLO [3.2.2] NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
- 专利标题: 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
- 专利标题(中): 1,4-DIAZA-BICYCLO [3.2.2] NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
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申请号: US12861420申请日: 2010-08-23
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公开(公告)号: US20100317654A1公开(公告)日: 2010-12-16
- 发明人: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel
- 申请人: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel
- 优先权: DKPA200600731 20060530
- 主分类号: A61K31/551
- IPC分类号: A61K31/551 ; A61P25/18 ; A61P25/28 ; A61P25/24 ; A61P25/22 ; A61P25/16 ; A61P25/00 ; A61P25/08 ; A61P25/06 ; A61P25/02 ; A61P29/00 ; A61P11/06 ; A61P9/10 ; A61P15/12 ; A61P9/12 ; A61P17/10 ; A61P1/12 ; A61P25/30 ; A61P25/32 ; A61P25/34 ; A61P25/36 ; A61P43/00
摘要:
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.