发明申请
- 专利标题: IMIDAZOBENZAZEPINE CGRP RECEPTOR ANTAGONISTS
- 专利标题(中): 咪达唑仑CGRP受体拮抗剂
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申请号: US12867332申请日: 2009-02-06
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公开(公告)号: US20100324023A1公开(公告)日: 2010-12-23
- 发明人: Howard G. Selnick , Ian M. Bell
- 申请人: Howard G. Selnick , Ian M. Bell
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 国际申请: PCT/US09/33288 WO 20090206
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; C07D487/14 ; C07D498/20 ; A61P25/06
摘要:
Compounds of Formula I: I (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
公开/授权文献
- US08796260B2 Imidazobenzazepine CGRP receptor antagonists 公开/授权日:2014-08-05
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