发明申请
US20100324045A1 CYCLIC UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
有权
11BETA-羟基脱氢酶脱氢酶的循环尿素抑制剂1
- 专利标题： CYCLIC UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
- 专利标题（中）： 11BETA-羟基脱氢酶脱氢酶的循环尿素抑制剂1
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申请号： US12745663申请日： 2008-11-07
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公开(公告)号： US20100324045A1公开(公告)日： 2010-12-23
- 发明人: David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
- 申请人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
- 专利权人： Vitae Pharmaceuticals, Inc.
- 当前专利权人： Vitae Pharmaceuticals, Inc.
- 国际申请： PCT/US08/12618 WO 20081107
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/506 ; C07D413/04 ; C07D401/10 ; A61K31/505 ; C07D239/02
摘要：
This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih)1 (Ij), (Ik), (Il1-3). (Im1-3), (In1-3), (Io1-2), (Ip1-6), (Iq1-6), (Ir1-6) and (Is1-2), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.