发明申请
- 专利标题： TRISUBSTITUTED 1,2,4 TRIAZOLES
- 专利标题（中）： 检测1,2,4三唑
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申请号： US12866054申请日： 2009-03-18
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公开(公告)号： US20100324053A1公开(公告)日： 2010-12-23
- 发明人: Gregor James MacDonald , Johannes Wilhelmus John F. Thuring , Pauline Carol Stanislawski , Wei Zhuang , Yves Emiel Maria Van Roosbroeck , Frans Alfons Maria Van Den Keybus
- 申请人： Gregor James MacDonald , Johannes Wilhelmus John F. Thuring , Pauline Carol Stanislawski , Wei Zhuang , Yves Emiel Maria Van Roosbroeck , Frans Alfons Maria Van Den Keybus
- 优先权： EP08152987.7 20080319
- 国际申请： PCT/EP2009/053186 WO 20090318
- 主分类号： A61K31/498
- IPC分类号： A61K31/498 ; A61K31/4439 ; A61K31/4196 ; C07D401/04 ; C07D405/10 ; A61P25/28 ; A61P25/22 ; A61P25/18 ; A61P25/24 ; A61P25/16 ; A61P25/34 ; A61P25/02 ; A61P25/00
摘要：
The present invention relates to 1-aryl-3-aniline-5-alkyl-1,2,4-triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
公开/授权文献
- US08778974B2 Trisubstituted 1,2,4 triazoles 公开/授权日：2014-07-15