发明申请
- 专利标题: Compounds and methods for development of Ret Modulators
- 专利标题(中): Ret调制剂开发的化合物和方法
-
申请号: US12082665申请日: 2008-04-11
-
公开(公告)号: US20100324065A1公开(公告)日: 2010-12-23
- 发明人: Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
- 申请人: Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
- 专利权人: Plexxikon Inc
- 当前专利权人: Plexxikon Inc
- 主分类号: A61K31/497
- IPC分类号: A61K31/497 ; A61K31/437
摘要:
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
公开/授权文献
- US08067434B2 Compounds and methods for development of Ret modulators 公开/授权日:2011-11-29