发明申请
US20100329979A1 Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test
审中-公开
使用呼吸试验评估细胞色素P450 2D6同工酶活性的方法和组成
- 专利标题： Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test
- 专利标题（中）： 使用呼吸试验评估细胞色素P450 2D6同工酶活性的方法和组成
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申请号： US12874350申请日： 2010-09-02
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公开(公告)号： US20100329979A1公开(公告)日： 2010-12-30
- 发明人: Anil S. Modak , Yasuo Irie , Yasuhisa Kurogi
- 申请人： Anil S. Modak , Yasuo Irie , Yasuhisa Kurogi
- 专利权人： Otsuka America Pharmaceutical, Inc.
- 当前专利权人： Otsuka America Pharmaceutical, Inc.
- 主分类号： A61K51/08
- IPC分类号： A61K51/08
摘要：
The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.
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