发明申请
US20100330120A1 HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES
审中-公开
具有分离的P和C基因的人类流感病毒病毒
- 专利标题: HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES
- 专利标题(中): 具有分离的P和C基因的人类流感病毒病毒
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申请号: US12599095申请日: 2008-05-08
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公开(公告)号: US20100330120A1公开(公告)日: 2010-12-30
- 发明人: Peter L. Collins , Brian R. Murphy , Mario H. Skiadopoulos , Emmalene J. Bartlett , Alexander C. Schmidt , Ann-Marie M. Cruz
- 申请人: Peter L. Collins , Brian R. Murphy , Mario H. Skiadopoulos , Emmalene J. Bartlett , Alexander C. Schmidt , Ann-Marie M. Cruz
- 国际申请: PCT/US08/63033 WO 20080508
- 主分类号: A61K39/155
- IPC分类号: A61K39/155 ; C12N7/01 ; C07H21/04 ; C12N7/04 ; A61P37/04 ; A61P31/14
摘要:
The invention provides self replicating infectious recombinant paramyxoviruses where the P and C genes are separated rated. The recombinant paramyxoviruses preferably have one or more attenuating mutations and/or at least one temperature sensitive mutation and one non-temperature sensitive mutation. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a C protein and a separate monocistronic polynucleotide encoding a P protein. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
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