发明申请
US20100330120A1 HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES 审中-公开
具有分离的P和C基因的人类流感病毒病毒

HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES
摘要:
The invention provides self replicating infectious recombinant paramyxoviruses where the P and C genes are separated rated. The recombinant paramyxoviruses preferably have one or more attenuating mutations and/or at least one temperature sensitive mutation and one non-temperature sensitive mutation. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a C protein and a separate monocistronic polynucleotide encoding a P protein. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
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