发明申请
- 专利标题： PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF
- 专利标题（中）： 苯乙酸，苯甲酸，苯丙酸和苯并三唑酸的共聚物及其制备方法及其应用
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申请号： US12828456申请日： 2010-07-01
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公开(公告)号： US20110002991A1公开(公告)日： 2011-01-06
- 发明人: Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- 申请人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- 主分类号： A61K9/28
- IPC分类号： A61K9/28 ; C07D489/04 ; A61K31/485 ; A61P29/00 ; A61P25/36 ; A61P25/30
摘要：
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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