Downhole tools for anchoring and isolating at least one zone in a wellbore comprise a mandrel having an upper end, a lower end, an outer wall surface, and a longitudinal bore disposed therethrough having an axis. One or more anchors are disposed through the outer wall surface of the mandrel. Each of the anchors has a retracted position and an extended position. An isolation element is disposed along the outer wall surface of the mandrel. The isolation element may cover the anchors or be disposed, above, below, or around the anchors. Engagement of the isolation element with the inner wall surface of the wellbore to isolate at least one zone of the wellbore may be accomplished by piercing the isolation element to permit wellbore fluid to contact a swellable material contained within the isolation element, or by pumping fluid into the isolation element.