发明申请
- 专利标题: Methods of Treating RSV Infections And Related Conditions
- 专利标题(中): 治疗RSV感染和相关条件的方法
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申请号: US12600292申请日: 2008-06-25
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公开(公告)号: US20110008329A1公开(公告)日: 2011-01-13
- 发明人: Subramaniam Krishnan , JoAnn Suzich , Peter Kiener , Genevieve Losonsky , Herren Wu , William Dall'Acqua , Bettina Richter
- 申请人: Subramaniam Krishnan , JoAnn Suzich , Peter Kiener , Genevieve Losonsky , Herren Wu , William Dall'Acqua , Bettina Richter
- 申请人地址: US MD Gaithersburg
- 专利权人: Medlmmune, LLC
- 当前专利权人: Medlmmune, LLC
- 当前专利权人地址: US MD Gaithersburg
- 国际申请: PCT/US08/68155 WO 20080625
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/10 ; A61P31/14 ; A61P37/04
摘要:
The present invention provides methods for managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom or a long-term respiratory condition relating thereto (e.g., asthma, wheezing, reactive airway disease (RAD), or chronic obstructive pulmonary disease (COPD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.
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