发明申请
US20110009609A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF
失效
2'-羟基保护的核糖核苷衍生物及其生产方法
- 专利标题： 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF
- 专利标题（中）： 2'-羟基保护的核糖核苷衍生物及其生产方法
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申请号： US12919295申请日： 2009-02-26
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公开(公告)号： US20110009609A1公开(公告)日： 2011-01-13
- 发明人: Hirofumi Maeda , Akio Fujii , Masaru Mitsuda
- 申请人： Hirofumi Maeda , Akio Fujii , Masaru Mitsuda
- 优先权： JP2008-050658 20080229
- 国际申请： PCT/JP2009/053482 WO 20090226
- 主分类号： C07H19/22
- IPC分类号： C07H19/22 ; C07H19/00
摘要：
The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.