A magnetic resonance sequence includes an interleaved slice-selective pre-pulse and a slice-selective multi-echo acquisition. This sequence is repeated with different delays between the pre-pulse and the acquisition resulting in a matrix of complex images. Based on this matrix T1 and T2 relaxations, proton density and the B1 field can be estimated. These quantified parameters enable synthetic magnetic resonance imaging (MRI) and form a robust input for tissue segmentation in computer aided diagnosis for MRI.