Invention Application
- Patent Title: Gene Expression Technique
- Patent Title (中): 基因表达技术
-
Application No.: US11993335Application Date: 2006-06-22
-
Publication No.: US20110020865A1Publication Date: 2011-01-27
- Inventor: Thomas Payne , Darrell Sleep , Christopher John Arthur Finnis , Leslie Robert Evans
- Applicant: Thomas Payne , Darrell Sleep , Christopher John Arthur Finnis , Leslie Robert Evans
- Applicant Address: GB Nottingham GB Nottingham
- Assignee: Novozymes Delta Limited,University of Nottigham
- Current Assignee: Novozymes Delta Limited,University of Nottigham
- Current Assignee Address: GB Nottingham GB Nottingham
- Priority: GB0512707.1 20050622
- International Application: PCT/GB06/02289 WO 20060622
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N1/19 ; C12N15/74
Abstract:
The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of two or more helper proteins selected from a DnaJ-like protein (such as JEM1), an Hsp70 family protein (such as LHS1) and SIL1 wherein at least one of the over-expressed two or more helper proteins is selected from JEM1, LHS1 and SIL1, and wherein the DnaJ-like protein is not SCJ1.
Information query
