发明申请
US20110021791A1 Method for preparing 4B-amino-4'-demethyl-4-desoxypodophyllotoxin
有权
制备4B-氨基-4'-去甲基-4-脱氧鬼臼毒素的方法
- 专利标题： Method for preparing 4B-amino-4'-demethyl-4-desoxypodophyllotoxin
- 专利标题（中）： 制备4B-氨基-4'-去甲基-4-脱氧鬼臼毒素的方法
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申请号： US12894684申请日： 2010-09-30
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公开(公告)号： US20110021791A1公开(公告)日： 2011-01-27
- 发明人: Yves Guminski , Martial Grousseaud , Thierry Imbert
- 申请人： Yves Guminski , Martial Grousseaud , Thierry Imbert
- 优先权： FR0507642 20050719
- 主分类号： C07D407/10
- IPC分类号： C07D407/10
摘要：
The invention relates to a method for synthesizing 4β-amino-4′-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4β-halogenoacetamido-4′-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4β-amino-4′-demethyl-4-desoxypodophyllotoxin.