发明申请
- 专利标题： QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS
- 专利标题（中）： 喹唑啉酮衍生物作为管状聚氨酯抑制剂
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申请号： US12934733申请日： 2009-03-26
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公开(公告)号： US20110028433A1公开(公告)日： 2011-02-03
- 发明人: Eddy Jean Edgard Freyne , Laurence Anne Mevellec , Jorge Eduardo Vialard , Christophe Meyer , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Patrick René Angibaud
- 申请人： Eddy Jean Edgard Freyne , Laurence Anne Mevellec , Jorge Eduardo Vialard , Christophe Meyer , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Patrick René Angibaud
- 申请人地址： BE Beerse FR ISSY-LES MOULINEAUX CEDEX 9
- 专利权人： JANSSEN PHARMACEUTICA NV,JANSSEN-CILAG
- 当前专利权人： JANSSEN PHARMACEUTICA NV,JANSSEN-CILAG
- 当前专利权人地址： BE Beerse FR ISSY-LES MOULINEAUX CEDEX 9
- 优先权： EP08153428.1 20080327
- 国际申请： PCT/EP2009/053604 WO 20090326
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; C07D403/06 ; C07D239/80 ; C07F7/10 ; C07D401/06 ; A61K31/695 ; C07D417/06 ; A61P35/00
摘要：
The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, n, m and X have defined meanings.
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