发明申请
US20110028445A1 Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
审中-公开
苯并吡喃和相关支架的尿素衍生物，含有此类化合物的药物及其用途
- 专利标题： Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
- 专利标题（中）： 苯并吡喃和相关支架的尿素衍生物，含有此类化合物的药物及其用途
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申请号： US12866125申请日： 2009-02-10
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公开(公告)号： US20110028445A1公开(公告)日： 2011-02-03
- 发明人: Matthias Eckhardt , Frank Himmelsbach , Bradford S. Hamilton , Stefan Peters
- 申请人： Matthias Eckhardt , Frank Himmelsbach , Bradford S. Hamilton , Stefan Peters
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP08151295.6 20080212
- 国际申请： PCT/EP09/00905 WO 20090210
- 主分类号： A61K31/4748
- IPC分类号： A61K31/4748 ; C07D401/06 ; C07D403/06 ; C07D413/06 ; C07D495/04 ; C07D471/04 ; C07D471/10 ; C07D401/14 ; A61K31/5377 ; A61K31/496 ; A61K31/55 ; A61K31/536 ; A61P3/00
摘要：
The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.