A tunable chromatic dispersion compensation device used to compensate chromatic dispersion of wavelength of at least one predetermined wavelength band of light signal is provided. The tunable chromatic dispersion compensation device comprises a chromatic dispersion compensator, and a controller. The chromatic dispersion compensator comprises at least a first chromatic dispersion compensation unit and a second chromatic dispersion compensation unit connected with the first chromatic dispersion compensation unit in series. The first chromatic dispersion compensation unit has a free spectral range, the second chromatic dispersion compensation unit has a free spectral range same as to that of the first chromatic dispersion compensation unit. Each chromatic dispersion compensation unit comprises an interference cavity. The controller comprises an inputting unit being configured for inputting a predetermined chromatic dispersion compensation information. The controller is configured for selectively adjusting refractive index of the interference cavity of a corresponding chromatic dispersion compensation unit so as to control chromatic dispersion. A tunable chromatic dispersion compensation is also provided.