A multi-panel sterilization assembly that includes a barrier panel formed of a permeable material, a fold protection panel, and at least one panel attachment means. The barrier panel has a first end and a second end opposite the first end such that the barrier panel has a length that is the distance from the first end to the second end and a midpoint along the length generally delineating the barrier panel into a content receiving region and a content covering region. Panel attachment means are located between the first end and the midpoint of the barrier panel at a pre-determined position to identify the content receiving region. The fold protection panel is in juxtaposed communication with the barrier panel, and has a proximal end generally adjacent the barrier panel, a distal end generally opposite the proximal end, and a length that is the distance between these ends, such that, after the barrier panel has been folded at or near the barrier panel's midpoint so its second end is brought near its first end and its edges brought together and secured by the panel attachment means to form a package, the fold protection panel folds at or near the pre-determined fold line to cover at least a portion of the edges of the folded barrier panel.