Invention Application
US20110039902A1 PROCESS FOR PREPARING A CRYSTALLINE FORM COMPOUND OF 3-BENZYL-2-METHYL-2,3,3a,4,5,6,7,7a-OCTAHYDROBENZO[d]ISOXAZOL-4-ONE
审中-公开
制备3-苄基-2-甲基-2,3,3a，4,5,6,7,7a-八氢噻吩并[d]异恶唑-4-酮的晶体形式化合物的方法
![PROCESS FOR PREPARING A CRYSTALLINE FORM COMPOUND OF 3-BENZYL-2-METHYL-2,3,3a,4,5,6,7,7a-OCTAHYDROBENZO[d]ISOXAZOL-4-ONE](/docs/US/2011-02-17/US20110039902A1/abs.jpg.600x600.jpg)
- Patent Title: PROCESS FOR PREPARING A CRYSTALLINE FORM COMPOUND OF 3-BENZYL-2-METHYL-2,3,3a,4,5,6,7,7a-OCTAHYDROBENZO[d]ISOXAZOL-4-ONE
- Patent Title (中): 制备3-苄基-2-甲基-2,3,3a，4,5,6,7,7a-八氢噻吩并[d]异恶唑-4-酮的晶体形式化合物的方法
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Application No.: US12989069Application Date: 2009-04-23
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Publication No.: US20110039902A1Publication Date: 2011-02-17
- Inventor: Fabio Neggiani , Elio Napolitano , Simone Basagni , Barbara Politi
- Applicant: Fabio Neggiani , Elio Napolitano , Simone Basagni , Barbara Politi
- Applicant Address: IT Ospedaletto
- Assignee: ABIOGEN PHARMA S.P.A.
- Current Assignee: ABIOGEN PHARMA S.P.A.
- Current Assignee Address: IT Ospedaletto
- Priority: ITMI2008A000768 20080424
- International Application: PCT/EP09/54859 WO 20090423
- Main IPC: A61K31/423
- IPC: A61K31/423 ; C07D261/20 ; A61P25/22 ; A61P25/24 ; A61P25/08 ; A61P25/30
![PROCESS FOR PREPARING A CRYSTALLINE FORM COMPOUND OF 3-BENZYL-2-METHYL-2,3,3a,4,5,6,7,7a-OCTAHYDROBENZO[d]ISOXAZOL-4-ONE](/abs-image/US/2011/02/17/US20110039902A1/abs.jpg.150x150.jpg)
Abstract:
A process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one is described, comprising the step of reacting 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydroben-zo[d]isoxazol-4-one with oxalic acid in one or more solvents, wherein at least one solvent is a solvent having a carbon atom number of from 3 to 6, said solvent being non-halogenated and having a dielectric constant ∈ within the range from 4 to 25. The process of the invention enables a co-crystal comprising 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one and oxalic acid to be obtained.
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