A wellbore instrument system includes a pipe string extending from earth's surface into a wellbore. At least a portion of the pipe string includes a signal communication channel having a cable, such as an electrical conductor or an optical fiber. At least one wireline configurable wellbore instrument is coupled to the pipe string and has at least one sensor therein for measuring a physical parameter. The at least one instrument is in signal communication with the signal communication channel in the pipe string. The system includes a controller functionally associated with the at least one instrument and configured to initiate operation of the at least one sensor upon detection of a command signal.