发明申请
US20110046049A1 Soluble, Stable Insulin-Containing Formulations with a Protamine Salt
有权
可溶性，稳定的含有鱼精蛋白盐的含胰岛素的制剂
- 专利标题： Soluble, Stable Insulin-Containing Formulations with a Protamine Salt
- 专利标题（中）： 可溶性，稳定的含有鱼精蛋白盐的含胰岛素的制剂
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申请号： US11791064申请日： 2005-11-21
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公开(公告)号： US20110046049A1公开(公告)日： 2011-02-24
- 发明人: Helle Birk Olsen , Niels Christian Kaarsholm , Per Balschmidt
- 申请人： Helle Birk Olsen , Niels Christian Kaarsholm , Per Balschmidt
- 申请人地址： DK Bagsvaerd
- 专利权人： NOVO NORDISK A/S
- 当前专利权人： NOVO NORDISK A/S
- 当前专利权人地址： DK Bagsvaerd
- 优先权： DKPA200401807 20041122; EP05104998.9 20050608
- 国际申请： PCT/EP05/56105 WO 20051121
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; A61P3/10
摘要：
The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of protamine, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the insulin peptide(s) contained in such formulations is indicated. The present invention further relates to methods for increasing the stability and/or solubility of insulin in insulin-containing formulations at a pH less than 7.0 by adding a salt of protamine to the insulin-containing formulations.
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