发明申请
- 专利标题: Anti-CD19 Antibodies
- 专利标题(中): 抗CD19抗体
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申请号: US12907262申请日: 2010-10-19
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公开(公告)号: US20110052489A1公开(公告)日: 2011-03-03
- 发明人: Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
- 申请人: Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
- 申请人地址: US NJ Morris Plains
- 专利权人: IMMUNOMEDICS, INC.
- 当前专利权人: IMMUNOMEDICS, INC.
- 当前专利权人地址: US NJ Morris Plains
- 主分类号: A61K51/10
- IPC分类号: A61K51/10 ; A61K39/395 ; A61K49/00 ; A61K38/21 ; A61K38/19 ; A61K49/22 ; A61P35/02 ; A61P37/06
摘要:
The present invention provides humanized, chimeric and human anti-CD19 antibodies, anti-CD19 antibody fusion proteins, and fragments thereof that bind to a human B cell marker. Such antibodies, fusion proteins and fragments thereof are useful for the treatment and diagnosis of various B-cell disorders, including B-cell malignancies and autoimmune diseases. In more particular embodiments, the humanized anti-CD19 antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. In a particularly preferred embodiment, the substitutions comprise a Ser91Phe substitution in the hA19 VH sequence.
公开/授权文献
- US08147831B2 Anti-CD19 antibodies 公开/授权日:2012-04-03
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