发明申请
US20110052501A1 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
审中-公开
多肽和多核苷酸，以及作为药物和生物学药物目标的用途
- 专利标题： POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
- 专利标题（中）： 多肽和多核苷酸，以及作为药物和生物学药物目标的用途
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申请号： US12863189申请日： 2009-02-01
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公开(公告)号： US20110052501A1公开(公告)日： 2011-03-03
- 发明人: Liat Dassa , Galit Rotman , Eve Montia , Avi Yeshah Rosenberg , Anat Cohen-Dayag , Amir Toporik , Zurit Levine , Shira Walach , Shirley Sameach-Greenwald , Yaron Kinar , Ofer Levy , Sergey Nemzar
- 申请人： Liat Dassa , Galit Rotman , Eve Montia , Avi Yeshah Rosenberg , Anat Cohen-Dayag , Amir Toporik , Zurit Levine , Shira Walach , Shirley Sameach-Greenwald , Yaron Kinar , Ofer Levy , Sergey Nemzar
- 国际申请： PCT/IL09/00123 WO 20090201
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C07K14/47 ; C07K16/18 ; A61K39/395 ; C12N9/96 ; G01N33/68 ; A61P35/00 ; A61P35/02 ; A61P35/04 ; A61P37/02 ; A61P19/02 ; A61P29/00 ; A61P25/00 ; A61P17/06 ; A61P37/06 ; G01N1/00
摘要：
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages. This invention further relates to the discovery of extracellular domains of KIAA0746 and its variants, CD20 and its variants, CD55 and its variants, which are suitable targets for immunotherapy, cancer therapy, treatment of inflammatory, allergic and autoimmune disorders, and drug development.
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