发明申请
US20110052579A1 Ligands of the Natural Killer (NK) Cell Surface Marker CD27 and Therapeutic Uses Thereof,
审中-公开
天然杀伤剂（NK）细胞表面标记物CD27及其治疗用途的配体，
- 专利标题： Ligands of the Natural Killer (NK) Cell Surface Marker CD27 and Therapeutic Uses Thereof,
- 专利标题（中）： 天然杀伤剂（NK）细胞表面标记物CD27及其治疗用途的配体，
-
申请号： US12864761申请日： 2009-02-16
-
公开(公告)号： US20110052579A1公开(公告)日： 2011-03-03
- 发明人: Siegfried Weiss , Nuno Viegas
- 申请人： Siegfried Weiss , Nuno Viegas
- 优先权： EP08002867.3 20080215
- 国际申请： PCT/EP2009/001065 WO 20090216
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/53 ; C40B30/04 ; C12N5/078 ; A61P31/16 ; A61P35/00
摘要：
The present invention relates to the modulation of Natural Killer (NK) cells in vitro or in vivo through the use of activating or inhibiting ligands of CD27, such as antibodies, for a regulation of the immune response against several different diseases, such as viral infections, cancer, bacterial infections, sepsis as well as immunological diseases. In a preferred embodiment, the inventors were able to improve the host resistance against Influenza virus and cancer through the application of anti-CD27 antibodies. In a different setting the inventors were able to prevent the onset of a lethal bacterial sepsis by preventing the activation of NK cells via CD27. The invention furthermore relates to screening assays for ligands of the surface marker CD27.
信息查询
