Invention Application
US20110053959A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
有权
作为AKT蛋白激酶抑制剂的PYRIMIDYL CYCLOPENTANES
- Patent Title: PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
- Patent Title (中): 作为AKT蛋白激酶抑制剂的PYRIMIDYL CYCLOPENTANES
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Application No.: US12812384Application Date: 2009-01-09
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Publication No.: US20110053959A1Publication Date: 2011-03-03
- Inventor: Anna Banka , Josef R. Bencsik , James F. Blake , Kin Chiu Fong , Martin F. Hentemann , Ian S. Mitchell , Douglas McCord Sammond , Tony P. Tang , Eli M. Wallace , Rui Xu
- Applicant: Anna Banka , Josef R. Bencsik , James F. Blake , Kin Chiu Fong , Martin F. Hentemann , Ian S. Mitchell , Douglas McCord Sammond , Tony P. Tang , Eli M. Wallace , Rui Xu
- Applicant Address: US CO Boulder
- Assignee: ARRAY BIOPHARMA INC.
- Current Assignee: ARRAY BIOPHARMA INC.
- Current Assignee Address: US CO Boulder
- International Application: PCT/US09/30603 WO 20090109
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D471/20 ; A61P7/00 ; A61P37/06 ; A61P3/10 ; A61P9/10 ; A61P31/12 ; A61P1/16 ; A61P25/28 ; A61P17/06 ; A61P29/00 ; A61P35/04 ; A61P35/00 ; A61P25/16
Abstract:
The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.
Public/Granted literature
- US08324221B2 Pyrimidyl cyclopentanes as Akt protein kinase inhibitors Public/Granted day:2012-12-04
Information query
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