A system with a boiler and a turbine, and an associated control method. The method includes sensing a plurality of operating conditions at a first common boiler location. At least one of the plurality of operating conditions sensed at the first common location is indicative of a combustion anomaly occurring during operation. The combustion anomaly indicated by the plurality of operating conditions at the first common location is traced back to an offending burner that is at least partially responsible for the combustion anomaly based on a model that takes into consideration at least two of the plurality of operating conditions sensed at the first common location. At least one of a process input and a boiler configuration is adjusted to establish a desired value of the operating conditions at the first common location.