发明申请
- 专利标题: Method for Opening Tight Junctions
- 专利标题(中): 打开紧密连接的方法
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申请号: US12682331申请日: 2008-10-13
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公开(公告)号: US20110064792A1公开(公告)日: 2011-03-17
- 发明人: Peter Humphries , Matthew Campbell , Anna-Sophia King
- 申请人: Peter Humphries , Matthew Campbell , Anna-Sophia King
- 优先权: EP07118412.1 20071012; IE2008/0743 20080912
- 国际申请: PCT/EP08/63734 WO 20081013
- 主分类号: A61K31/7088
- IPC分类号: A61K31/7088 ; A61K9/127 ; A61K38/00 ; A61K38/43 ; A61P25/28 ; A61P25/00 ; A61P35/00 ; A61P27/02 ; C12N5/071
摘要:
The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.
公开/授权文献
- US09540649B2 Method for opening tight junctions 公开/授权日:2017-01-10