A signal path configuration method and apparatus of a wireless device are provided for avoiding radiation performance degradation caused by holding a specific part of the wireless device. A wireless device of the present invention includes a Radio Frequency (RF) unit that includes a plurality of antennas, an RF connector for RF calibration, and a detection unit for detecting connection of an RF cable, a switch for switching a signal path to one of the plurality of antennas, and a control unit for distinguishing between communication modes based on a detection signal output by the detection unit and for generating a control signal for controlling the switch to connect the signal path to one of the antennas according to the communication mode.