发明申请
- 专利标题： AGENTS AND METHODS FOR ANALYZING PROTEIN INTERACTIONS
- 专利标题（中）： 用于分析蛋白质相互作用的试剂和方法
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申请号： US12705828申请日： 2010-02-15
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公开(公告)号： US20110070596A1公开(公告)日： 2011-03-24
- 发明人: Nichole Lea Wood , Mohan Mark Amaratunga , Hans Grade , Faisal Ahmed Syud , Anup Sood , Reginald Donovan Smith , Ayse Betul Dinc , Amy Casey Williams , Anthony John Murray , Gregory Daryll Goddard
- 申请人： Nichole Lea Wood , Mohan Mark Amaratunga , Hans Grade , Faisal Ahmed Syud , Anup Sood , Reginald Donovan Smith , Ayse Betul Dinc , Amy Casey Williams , Anthony John Murray , Gregory Daryll Goddard
- 申请人地址： US NY Schenectady
- 专利权人： GENERAL ELECTRIC COMPANY
- 当前专利权人： GENERAL ELECTRIC COMPANY
- 当前专利权人地址： US NY Schenectady
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; C07D403/12 ; G01N33/53
摘要：
Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.
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