Invention Application
- Patent Title: Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics
- Patent Title (中): 利用药物伴侣改善生物制剂的制造和纯化
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Application No.: US12788068Application Date: 2010-05-26
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Publication No.: US20110070643A1Publication Date: 2011-03-24
- Inventor: Hung V. Do
- Applicant: Hung V. Do
- Main IPC: C12N5/07
- IPC: C12N5/07
Abstract:
The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell.
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