发明申请
- 专利标题： ANTI-VEGF ANTIBODIES
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申请号： US12962514申请日： 2010-12-07
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公开(公告)号： US20110081342A1公开(公告)日： 2011-04-07
- 发明人: MANUEL BACA , JAMES A. WELLS , LEONARD G. PRESTA , HENRY B. LOWMAN , YVONNE MAN-YEE CHEN
- 申请人： MANUEL BACA , JAMES A. WELLS , LEONARD G. PRESTA , HENRY B. LOWMAN , YVONNE MAN-YEE CHEN
- 申请人地址： US CA SOUTH SAN FRANCISCO
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 当前专利权人地址： US CA SOUTH SAN FRANCISCO
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/22 ; C07H21/04 ; A61P35/00 ; A61P27/02 ; C12P21/08 ; C12N15/85
摘要：
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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