- 专利标题： INHIBITORS OF JANUS KINASES
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申请号： US12999342申请日： 2009-06-08
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公开(公告)号： US20110082136A1公开(公告)日： 2011-04-07
- 发明人: Michelle Machacek , Gabriela de Almeida , Jonathan B. Grimm , Rachel N. MacCoss , Eric Romeo , Tony Siu , Catherine White , Kevin Wilson
- 申请人： Michelle Machacek , Gabriela de Almeida , Jonathan B. Grimm , Rachel N. MacCoss , Eric Romeo , Tony Siu , Catherine White , Kevin Wilson
- 国际申请： PCT/US09/46597 WO 20090608
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/502 ; A61K31/495 ; A61K31/519 ; A61K31/4375 ; A61K31/437 ; C07D487/04 ; C07D513/04 ; C07D498/04 ; C07D471/04
摘要：
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
公开/授权文献
- US08344144B2 Inhibitors of Janus kinases 公开/授权日：2013-01-01