发明申请
US20110085979A1 CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS
有权
聚合物，抗血管发生剂和靶向药物的联合使用及其在治疗骨髓相关血管生成条件中的应用
- 专利标题： CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS
- 专利标题（中）： 聚合物，抗血管发生剂和靶向药物的联合使用及其在治疗骨髓相关血管生成条件中的应用
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申请号： US12993855申请日： 2009-05-21
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公开(公告)号： US20110085979A1公开(公告)日： 2011-04-14
- 发明人: Ronit Satchi-Fainaro , Ehud Segal , Jindrich Kopecek , Pavla Kopeckova , Huaizhong Pan
- 申请人： Ronit Satchi-Fainaro , Ehud Segal , Jindrich Kopecek , Pavla Kopeckova , Huaizhong Pan
- 申请人地址： IL Tel-Aviv US UT Salt Lake City
- 专利权人： Ramot at Tel-Aviv University Ltd.,University of Utah Research Foundation
- 当前专利权人： Ramot at Tel-Aviv University Ltd.,University of Utah Research Foundation
- 当前专利权人地址： IL Tel-Aviv US UT Salt Lake City
- 国际申请： PCT/IL09/00511 WO 20090521
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A61K31/787 ; A61P35/00 ; A61P19/08 ; C08F8/40 ; A61P35/04 ; C07K17/10 ; C07K17/08
摘要：
Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed.Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
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