A handheld electronic device having a slide-and-twist mechanism for changing between multiple device positions is provided. A slide-and-twist style form factor allows the device configuration and/or exposed input devices to be changed by the device user. The different device positions may support different operational modes or uses of the device by exposing different input devices. In accordance with one embodiment, there is provided a handheld electronic device, comprising: a first body having a first face and a second face; a second body having a first face and a second face, the first and second input devices being located on the first face of the second body; the first body being connected to the second body for sliding movement between a closed position and a first open position, wherein in the closed position the first body covers at least a portion of the second body, and wherein in the first open position the first input device is exposed on the first face of the second body; and wherein the second body is rotatable relative to the first body between the first open position and a second open position, wherein in the second open position the second input device is exposed on the first face of the second body.