发明申请
US20110091375A1 USE OF THE COMBINATION COMPRISING TEMOZOLOMIDE AND TNF-ALPHA FOR TREATING GLIOBLASTOMA
审中-公开
包含TEMOZOLOMIDE和TNF-ALPHA联合治疗GLIOBLASTOMA的应用
- 专利标题： USE OF THE COMBINATION COMPRISING TEMOZOLOMIDE AND TNF-ALPHA FOR TREATING GLIOBLASTOMA
- 专利标题（中）： 包含TEMOZOLOMIDE和TNF-ALPHA联合治疗GLIOBLASTOMA的应用
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申请号： US12971953申请日： 2010-12-17
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公开(公告)号： US20110091375A1公开(公告)日： 2011-04-21
- 发明人: Ralph R. Weichselbaum , Donald W. Kufe , Bakhtiar Yamini
- 申请人： Ralph R. Weichselbaum , Donald W. Kufe , Bakhtiar Yamini
- 申请人地址： US IL Chicago US MA Boston
- 专利权人： THE UNIVERSITY OF CHICAGO,DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人： THE UNIVERSITY OF CHICAGO,DANA-FARBER CANCER INSTITUTE, INC.
- 当前专利权人地址： US IL Chicago US MA Boston
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C12N5/09 ; A61K38/19 ; A61K31/4188 ; A61K35/76 ; A61P35/00
摘要：
Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Also disclosed are methods of synergistically inhibiting growth of a glioma in a human cancer patient comprising administering temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Pharmaceutical combinations and therapeutic combinations suitable for use in the methods of the invention are also disclosed.
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