发明申请
US20110091452A1 4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
审中-公开
4,5-Dihydromacbecin衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用
- 专利标题： 4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
- 专利标题（中）： 4,5-Dihydromacbecin衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用
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申请号： US12294175申请日： 2007-03-30
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公开(公告)号： US20110091452A1公开(公告)日： 2011-04-21
- 发明人: Christine Martin , Ming Zhang , Sabine Gaisser , Nigel Coates , Barrie Wilkinson
- 申请人： Christine Martin , Ming Zhang , Sabine Gaisser , Nigel Coates , Barrie Wilkinson
- 优先权： GB0606527.0 20060331; GB0614607.0 20060722
- 国际申请： PCT/EP2007/053129 WO 20070330
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07D225/06 ; A61K31/395 ; A61K31/519 ; A61K31/704 ; A61K31/573 ; A61K38/14 ; A61K31/675 ; A61K31/513 ; A61K31/337 ; C12P17/10 ; C12N5/07
摘要：
The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
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