发明申请
- 专利标题: NUCLEOTIDE ANALOGUES WITH QUATERNARY CARBON STEREOGENIC CENTERS AND METHODS OF USE
- 专利标题(中): 具有季碳异体中心的核苷类似物及其使用方法
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申请号: US12933291申请日: 2009-03-18
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公开(公告)号: US20110092451A1公开(公告)日: 2011-04-21
- 发明人: Yvan Guindon
- 申请人: Yvan Guindon
- 申请人地址: CA Montreal
- 专利权人: INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL
- 当前专利权人: INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL
- 当前专利权人地址: CA Montreal
- 国际申请: PCT/IB09/05470 WO 20090318
- 主分类号: A61K31/7076
- IPC分类号: A61K31/7076 ; A61K31/7056 ; A61K31/7068 ; C07H19/04 ; C07H19/16 ; C07H19/06 ; A61P31/14 ; A61P31/18 ; A61P35/00 ; A61P31/16
摘要:
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3′ position. The nucleotide analogues can be used to inhibit cancer or viruses. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting diseases or conditions associated with cancers and viruses. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit viruses or tumors and treat, prevent, or inhibit the foregoing diseases.
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