Techniques for performing power control during discontinuous transmission (DTX) operation are described. A UE transmits on the uplink during a transmission burst and receives TPC commands generated by a Node B based on the uplink transmission. The UE may receive two TPC commands at the end of the transmission burst that are not applied during the transmission burst. The UE saves and applies these two TPC commands in the next transmission burst. In one design, the UE applies each saved TPC command in one slot of the next transmission burst. In another design, the UE combines the two saved TPC commands and applies the combined value in the first two slots of the next transmission burst. In yet another design, the UE selects one of the saved TPC commands and applies the selected TPC command in the first two slots of the next transmission burst.