发明申请
- 专利标题： Pegylated Insulin Lispro Compounds
- 专利标题（中）： 聚乙二醇化胰岛素溶解素
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申请号： US12997254申请日： 2009-06-09
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公开(公告)号： US20110105392A1公开(公告)日： 2011-05-05
- 发明人: John Michael Beals , Gordon Butler Cutler, JR. , Brandon Lee Doyle , Ryan John Hansen , Shun Li , Shahriar Shirani , Lianshan Zhang
- 申请人： John Michael Beals , Gordon Butler Cutler, JR. , Brandon Lee Doyle , Ryan John Hansen , Shun Li , Shahriar Shirani , Lianshan Zhang
- 申请人地址： US IN Indianapolis
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： US IN Indianapolis
- 国际申请： PCT/US09/46704 WO 20090609
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; C07K14/62 ; A61P3/10
摘要：
The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.