发明申请
- 专利标题： Novel Lapachone Compounds And Methods of Use Thereof
- 专利标题（中）： 新型Lapachone化合物及其使用方法
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申请号： US13004278申请日： 2011-01-11
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公开(公告)号： US20110105470A1公开(公告)日： 2011-05-05
- 发明人: Mark A. Ashwell , Manish Tandon , Jean-Marc Lapierre , Syed Ali , David Vensel , Chiang J. Li
- 申请人： Mark A. Ashwell , Manish Tandon , Jean-Marc Lapierre , Syed Ali , David Vensel , Chiang J. Li
- 申请人地址： US MA Woburn
- 专利权人： ArQule, Inc.
- 当前专利权人： ArQule, Inc.
- 当前专利权人地址： US MA Woburn
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D497/10 ; A61K31/438 ; C07D413/14 ; A61K31/5377 ; C07D223/14 ; A61K31/497 ; A61P35/00
摘要：
The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as β-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).
公开/授权文献
- US08039503B2 Lapachone compounds and methods of use thereof 公开/授权日：2011-10-18
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